Author: daryna muravenko

Every popular product or ingredient goes through three distinct stages: obscurity, in which shoppers are unaware of its existence; growth, in which sales explode; and maturity, in which demand for the product or ingredient stabilizes with supply.

Knowing that the CBD market will inevitably reach maturity, investors and brands have begun to open markets for additional non-intoxicating cannabinoids found in hemp. Chief among these “minor cannabinoids” are cannabigerol (CBG) and cannabinol (CBN), both of which are reasonably easy to produce even though they seem to offer many distinct benefits.

Recently, new data came to light indicating that future prospects for CBD and CBG are brighter than we previously believed. In this guide, we’ll examine a recent report from market analyst BDSA that illustrates incredible gains in the CBG and CBN industries during 2022.

US cannabinoid growth trends: An overview

The BDSA report, entitled “CBN and CBG Sales See Rapid Growth as CBD Sales Slow in Cannabis Markets¹,” begins by outlining the overall situation in the cannabinoids CBD, CBG, and CBN find themselves in light of prevailing hemp market trends. Noting that shoppers turn to cannabinoids for “a diverse set of need states,” BDSA goes on to point out that “CBD, CBN, and CBG can be utilized to better position a brand’s products as a support for needs like sleep and pain relief.”

Then, BDSA reminds us that CBG and CBN can be great tools for differentiation in CBD products, something that many brands have clearly noticed. Compared to even a year ago, there’s now a notable profusion of CBD products that also include CBG, CBN, or another minor cannabinoid.

Whether it’s due to the presence of CBG and CBN products online and on shelves, increased consumer interest in the two cannabinoids, or a combination of both factors, awareness of CBG and CBN has definitely increased since 2019. According to BDSA, only 11% of shoppers were aware of CBN and only 8% were aware of CBG in the fall of 2019, which swelled to 14% and 13% respectively by fall of 2021.

The latest BDSA data

Overall, BDSA found that around 70% more products contained CBN across California, Colorado, Illinois, Massachusetts, Michigan, Nevada, and Oregon in Q1 2022 compared to Q1 2021. For CBG, the number of products containing the cannabinoid doubled across the same markets.

BDSA provides much more detailed data regarding the percentage change CBD, CBG, and CBN experienced in the adult-use cannabis markets of California, Colorado, Nevada, and Oregon, which analysts consider to have reached relative maturity. In some cases, CBG and CBN sales have increased in quadruple-digit percentages year-over-year, leading many to hope that there is still a great deal of room for both cannabinoids to grow.

CBG sales are exploding

CBG sales increase in Q1 2022 compared to Q1 2021:

• California: +655%
• Colorado: +1251%
• Nevada: +1105%
• Oregon: +1185%

In the future, 2022 will likely be remembered as the year that CBG fully caught on within the mainstream of cannabis and hemp culture. On average, sales of this cannabinoid increased by around 10 times across four of the nation’s most mature adult-use cannabis markets. Some of the most impressive gains were to be found in Colorado and Oregon.

This year, those who keep their ear to the ground on social media have noticed a trend among chronic pain sufferers. It’s now trending to combine CBD and CBG, which is said to provide better effects for chronic pain. It’s partially to this viral trend that we must attribute the surge of CBG in areas that are clearly not cannabinoid-naive.

It’s possible that sales increases like these can only last for so long. We won’t know until we try, however, and as we speak, countless brands are doing all they can to continue expanding the CBG markets in California, Oregon, Nevada, Colorado, and beyond.

CBN sales are gaining

CBN sales increase in Q1 2022 compared to Q1 2021:

• California: +29%
• Colorado: +145%
• Nevada: +30%
• Oregon: +22%

Compared to CBG, sales of CBN are not growing as fast in CA, CO, NV, and OR, but it’s hard to follow up the incredible numbers CBG boasted last year. And, to be fair, the CBN market growing by two-and-a-half times in Colorado is nothing to bat an eyelash at. Overall, CBN experienced ~50% gains in America’s most mature cannabis markets in 2022, a number that can certainly be increased in 2023.

If you’ll recall back to the beginning of the article, BDSA found that a greater share of consumers are aware of CBN than are aware of CBG. The likely cause of the discrepancy between CBG and CBN growth in 2022, then, is simply that a greater number of CBG products are currently available on the market.

The closer that the ratio of CBN to CBG products on the market nears 1:1, the greater the sales percentages CBN will boast in markets like California and Oregon. Right now, it simply seems that shoppers have a hard time buying the CBN they want, a situation brands can start rectifying immediately.

CBD sales are holding steady

In states like California, Oregon, Nevada, and Colorado that have already had CBD for a long time, BDSA noted a moderate decline in sales volume in 2022. States that are newer to cannabis and hemp overall, though, posted CBD sales increases in 2022 — including Arizona, Illinois, and Massachusetts.

Even though the boom days of CBD appear to be on the wane, that’s not bad news. Market maturity provides brands with greater security, and the only payoff is being subject to greater regulation and transparency, which no reputable cannabinoid brand should fear.

There are also still plenty of states that show impressive yearly CBD sales increases. The CBD products that will do the best in both mature and naive markets are those that begin incorporating CBN, CBG, and other minor cannabinoids.

Popular CBG and CBN product categories

According to the BDSA report, gummies lead the race when it comes to product categories most likely to contain either CBG or CBN. Apparently, around 75% of CBN product sales were attributed to gummies with the figure being 70% for CBG.

Tinctures made up 5% of CBN sales and 10% of CBG sales in 2022, and each cannabinoid is also about 5% likely to be sold in the form of an edible product. Clearly, gummies are the vehicle by which CBN and CBG are becoming familiar to shoppers, a trend brands should expand upon while also encouraging shopper interest in other product types.

Analysis

What does this new information from BDSA tell us about best practices when producing and selling CBG and CBN products in 2023 and beyond? Below, we’ll unpack some of the subtler points of BDSA’s analysis to provide some concrete directions on how to proceed in this rapidly evolving submarket:

Shoppers are more knowledgeable

First, it’s important to recognize that, slowly but surely, a greater number of shoppers are becoming aware of CBG, CBN, and their potential uses. With this overall increase of awareness come two separate benefits: Shoppers are increasingly seeking out CBN and CBG specifically, and educated shoppers who come across these cannabinoids will not be turned away.

More products contain CBG and CBN

It’s a fact that a greater number of products contain CBG and CBN, which is part of the reason overall sales of these cannabinoids have increased so impressively over the last year. The growth each cannabinoid has shown should be viewed differently.

Growth percentages in the thousands are generally not sustainable. During 2022, the market became considerably more saturated with CBG, so adding CBG products to the market now is not guaranteed to yield 2022-level returns.

At the same time, CBN’s slower overall growth in 2022 compared to CBG is at odds with lower levels of consumer awareness of CBG compared to CBN. As long as they are positioned correctly, CBN products may be capable of even more growth in 2023 and beyond than CBG products showed in 2022.

CBD market approaches maturity

The CBD market reaching maturity has a variety of important implications. On the one hand, it means that hemp cannabinoids have finally been accepted into the mainstream, a moment proponents have long awaited.

Though in a positive sense, CBD should be viewed as a cannabinoid “Trojan horse” that has now made its way through the barricades and defenses of shopper skepticism. Inside are CBG, CBN, and a whole host of other cannabinoids that intend to spread healing without causing intoxication.

“[M]inor cannabinoids have huge potential to generate sales growth”

In its closing statements, BDSA concludes that the potential of CBG, CBN, and other minor cannabinoids to generate sales growth is nothing short of “huge.” The two factors prompting this increase, BDSA suggests, are expanding consumer knowledge and a greater number of CBG and CBN products being available.

Minors are replacing indica/sativa concerns

According to BDSA, products including minor cannabinoids like CBN and CBG should primarily be designed to produce repeatable experiences that will ultimately lead shoppers to choose hemp products based on the cannabinoids they contain. The market is currently preoccupied with questionable differences between indica, sativa, and hybrid products, and minor cannabinoids could provide the genuine, chemically explicable diversity of experience the mature hemp market has clearly begun to crave.

Sources

1. 1. Rice, A. (2022, June 7). CBN Sales & CBG Sales See Rapid Growth as CBD Sales Slow. BDSA. https://bdsa.com/cbn-and-cbg-sales-see-rapid-growth/

It’s no secret that Americans are having trouble getting quality sleep. Whether it’s because of stress at work, anxiety, tech overload, or even the inability to relax, sometimes we just can’t seem to shut down. The problem is so widespread it’s becoming an epidemic.

A new report released in 2022, The State of Sleep In America, surveyed Americans and found that nearly one-third of adults (33%), or around 84 million people, regularly experience “poor” to “fair” sleep. Furthermore, over half (55%) of Americans say that sleeping well is a “major priority,” placing it higher on their priority list than other lifestyle factors, such as social interaction (45%) or healthy eating (40%).

While there may not be a one-size-fits-all solution to the problem, industry experts anticipate cannabis entrepreneurs have the potential to make a real difference with CBN (cannabinol) as a natural sleep aid. According to industry experts, sleep research funding by the National Institutes for Health (NIH) is expected to reach $520 million in 2023, nearly doubling what it was just a decade ago.

And while sleep deprivation continues sweeping the nation, studies indicate that CBN might be what people need to combat lack of sleep.

In this blog post, we’ll explore America’s sleep crisis and examine CBN’s potential to help those struggling with their snooze cycle get a better night’s sleep.

Sleep 101: The Basics

Typically, when it comes to the pursuit of quality sleep, Americans don’t often think cannabis would be involved. But, given the specific effects of certain cannabinoids on different stages of the sleep cycle, knowledgeable cannabis enthusiasts take a keen interest in understanding their body and their sleep needs.

For them, getting to grips with what they need and why they may suffer from a lack of sleep can help shape the type of cannabis products that would best serve them.

And while we may not all be experts in cannabis or sleep deprivation, it’s worth brushing up on some sleep basics before learning why Americans are facing such severe deprivation and how the herb might just save the day (or night).

A Breakdown of Sleep Needs According to Age

Sleep needs change across the lifespan. In general, experts recommend: 

– Newborns through the first year: up to 18 hours daily
– Ages 1-3: 12-15 hours daily
– Ages 3-5: 11-13 hours daily
– Ages 2-12: 9-11 hours daily
– Teens: 9-10 hours daily
– Adults: 7- 8 hours daily

Sleep Stages: An Overview

As a general guideline, sleep consists of the following stages:

– Stage W (Wakefulness)
– Stage N1
– Stage N2
– Stage N3
– Stage R (Rapid Eye Movement, or REM)

Healthy sleepers cycle between the different stages of sleep every 90 minutes during an eight-hour sleep period. Let’s examine each stage in greater detail to see how they help us recharge.

Stage N1

Stage N1 occurs during the transition from wakefulness to sleepiness. Although this brief stage lasts between five to ten minutes, dreams may also occur during this time. While dozing off, the mind is still aware of its surroundings and can be easily roused back to awakeness.

During this phase, there is also a slowing of the brain waves, eye movements, heartbeat, and breathing. The muscles of the body may twitch as relaxation occurs.

Stage N2

After passing Stage N1, the process moves onto Stage N2, during which breathing and heart rate will continue to slow. Throughout the night, Stage N2 should account for about half of the total sleep time. This stage has the following characteristics:

– A lost sense of surroundings
– A decreased internal body temperature
– No eye movement
– Changes in breathing pattern

Also, during this time, the brain produces sleep spindles, characterized by bursts of fast, rhythmic brain waves. Sleep spindles are essential for memory consolidation, when the brain collects, organizes and filters new memories from the previous day.

Additionally, the body takes an even more relaxed state so that it is ready to enter stage N3 and REM, the deepest sleep stages in which the body and mind can recover, rejuvenate, and prepare for the next day.

Stage N3

Stage N3 is also known as Slow Wave Sleep or Delta Sleep due to slowed delta brain waves present during this stage of sleep. During N3 sleep, the body’s miraculous self-healing and repair process occurs, facilitated by the secretion of growth hormone.

In Stage N3, the first segment usually lasts 45-90 minutes. As the night progresses, the duration of subsequent segments of N3 sleep gradually shortens. This stage has the following key characteristics:

– Full muscle relaxation
– Slowed breathing and decreased blood pressure
– Transition to the deepest sleep stage

It is also important to note that N3 sleep diminishes with age, to the point that it can even be absent from seniors at night. Nevertheless, this does not indicate disease or disorder as it happens to healthy sleepers as well.

Stage R (REM)

Stage R is called REM sleep or “rapid eye movement” sleep. REM sleep usually begins between 90 and 110 minutes after falling asleep, with subsequent cycles occurring every 90 minutes.

Over the course of the night, REM sleep periods become longer and longer. Also, the heart rate increases during this cycle, and irregular breathing occurs. Additionally, the dreaming process happens during REM sleep. Stage R dreams tend to be remembered by healthy sleepers.

A particularly clever feature of the body is that it creates chemicals that temporarily paralyze the sleeper to prevent them from ‘acting out’ in their dreams. And for good reason, since people tend to be very active at this stage despite being asleep. In this cycle, the eyes dart back and forth rapidly, just as they do when awake.

Understanding Sleep Disorders and Disruptions

Sleep disorders and disruptions can be an absolute nightmare. Not only are they disruptive to quality of life, but they can also be a sign of something more serious. In light of that, here are a few of the most common sleep disorders and disruptions and how they may interfere with getting a good night’s sleep.

Insomnia

Insomnia occurs when there is difficulty initiating or staying asleep. Early morning awakenings can also occur, where an individual wakes up several hours before their normal schedule and is unable to fall back to sleep. As a result, individuals experience excessive sleepiness during the day, typically resulting in functional impairments during the daytime.

Narcolepsy

Narcolepsy is characterized by excessive daytime sleepiness (including episodes of irresistible sleepiness) and sudden muscle weakness. In narcolepsy, sudden muscle weakness can be triggered by strong emotions or surprise. The onset of narcolepsy is commonly referred to as a “sleep attack” and can occur even when walking or doing other physical activities.

Restless Leg Syndrome (RLS)

The symptoms of RLS include unpleasant “creeping” sensations, often originating in the lower legs but accompanied by aches and pains across the legs. It may cause difficulty falling asleep and is relieved by moving the legs, such as walking or kicking.

Sleep Apnea

There is more to snoring than just being annoying. It could be an indication of sleep apnea, characterized by rapid gasping or snorting noises, causing sleep to be interrupted momentarily. Due to frequent interruptions during sleep, those with sleep apnea may also feel excessively sleepy during the day.

Sleep Disruptions

Sleep disruptions can significantly impact individual performance and physical and mental health, leading to increased sluggishness, irritability, and difficulty focusing during the day. For instance, third-shift workers often experience disturbances in natural circadian rhythms and melatonin secretion. Melatonin is necessary for other hormone regulation functions within the body, so repeated disruption can lead to even more complicated issues.

Sleep disturbances resulting from frequent nighttime trips to the bathroom or night sweats can also lead to a compromised ability to concentrate and make decisions.

Perhaps most significant of all is jet lag – the disruption in biological rhythms caused by traveling quickly through multiple time zones that affects sleep, eating, and activity patterns.

All of this disruption can significantly impact an individual’s energy levels, moods, motivation, and ability to function optimally. Getting proper restorative sleep is essential for all individuals striving to maintain good health and productivity.

Americans’ Top Priority Is Sleep, Yet Sleep Quality Remains Low

It is well known that a lack of quality sleep is linked to a lack of overall well-being, which is why it’s no surprise that sleep is the number one priority for Americans. With long work hours, excessive screen time, and hectic lifestyles, overthinking the day’s earlier events and trying to shut off racing thoughts can make getting a good night’s rest feel like an unattainable dream. In the 2022 sleep report, a staggering 81% of Americans say their mental activity — thinking, racing thoughts, and feelings — keeps them awake at night.

Although sleep is recognized as being paramount, sleep quality remains low among many people. Mental health, age, mattress satisfaction, and sex are also closely linked to sleep quality. For example, more women than men say sleep is a top priority (61% vs. 48%, respectively) and worry more about losing sleep.

In addition, Americans’ poor sleep quality also impacts overall economic growth and is linked to weak GDP growth. Research shows the American economy loses an estimated $44.6 billion per year in unscheduled absences among workers as a consequence of poor sleep.

In their quest for relief, Americans are increasingly turning to sleep aids to improve their sleep quality. The most recent statistics show Americans spent $437 million on OTC sleep aids in 2021, double their 2011 spending of $217 million.

The market for natural sleep aids, however, is one worth watching, as it is expected to continue growing. In the wake of America’s crumbling marijuana prohibition, many are turning to health-promoting cannabinoids to find natural sleep remedies.

One phytocannabinoid that has shown promise as a natural sleep aid is cannabinol (CBN).

What Is the Cannabinoid CBN?

CBN is a phytocannabinoid found naturally in high amounts in aged cannabis plants. Unknown to most people is that CBN is actually the very first cannabinoid isolated in 1896 by Thomas Barlow Wood, WT Newton Spivey, and Thomas Hill Easterfield.

With its sedative properties and predominant presence in older cannabis flowers, CBN was often considered a less desirable cannabinoid than CBD or THC. However, despite being the “original” phytocannabinoid, CBN can be regarded as a “sleeper” cannabinoid since in the past, it wasn’t nearly as popular as THC, CBD, or terpenes.

The Unique Connection Between CBN and THC

Scientists now recognize CBN as a major cannabinoid, stemming from a 1999 study done by the United Nations Office on Drugs and Crime (UNODC). In the study, cannabis samples tested after four years were found to contain half of their original THC concentration. In addition, THC converted to CBN as it oxidized and dissipated.

According to the study, the most THC degradation occurred after two years of improper storage, indicating a strong relationship between the conversion of THC to CBN and the vulnerability of the plants.

The study revealed that over time, THC degrades into CBN. Thus the longer cannabis ages, the more CBN it will contain. As a result of the study, researchers have learned how CBN and THC cannabinoids interact differently with CB2 and CB1 receptors.

What Sets CBN Apart From CBD?

Even though they have similar names, CBD and CBN are entirely different molecules. The two cannabinoids are present in both marijuana and hemp (a cannabis subspecies with less than 0.3% THC) originating from CBGA. While some similarities have been discovered regarding their ability to address pain and inflammation, they differ primarily in their intended purposes.

Additionally, CBD has been extensively researched, and studies have revealed its anti-inflammatory, anxiolytic, and anticonvulsant properties. Thus, it serves as an industry staple and powerful therapeutic used by people seeking relief from anxiety, and epilepsy, among others.

And while some research suggests CBN may also possess anticonvulsant properties, most current research focuses on its ability to relax the mind and induce sleep.

The following are notable differences between CBN and CBD:

– A significant amount of CBD is found in hemp plants, making it more accessible and affordable.
– There is more research and understanding of CBD than CBN at present.
– CBN is formed by oxidizing THC, while decarboxylating CBDA present in raw cannabis flowers produces CBD.
– The FDA has approved one CBD-based medication for treating epilepsy/seizures, whereas CBN has not been approved.
– The two compounds are technically psychoactive, but CBD leaves the user unintoxicated, while CBN alters the mind very mildly due to its THC roots.
– CBD reduces appetite, whereas CBN stimulates it.

Although CBN and CBD each have unique benefits and effects, they are likely to complement one another well when combined. When cannabinoids are consumed together, they synergistically amplify each other’s actions, according to a phenomena called the entourage effect. Several studies have demonstrated the entourage effect, including a study showing the combined effects of CBN and CBD reduced pain in rats more effectively than either compound alone.

Does CBN Help With Sleep?

CBN-containing products are marketed as sleep aids by many companies, but does CBN actually alleviate insomnia and sleeplessness? As of yet, we’re still waiting for any solid insights.

Due to decades of cannabis prohibition, the amount of study has been limited, making it difficult to draw any definitive conclusions about the cannabinoid, even though it seems more effective when combined with other cannabinoids such as THC.

Historically, most of the research on cannabinol effects, particularly sedation, has been conducted on rodents. For example, a 1975 study found that CBN increased the sedative effects of THC in mice and rats.

As part of another groundbreaking 1975 clinical trial, five male participants were given various amounts of THC and CBN. Scientists found that ingesting THC and CBN together resulted in more substantial sedative effects than consuming THC alone.

In addition, during the study, participants’ heart rates increased with THC but not with CBN, further indicating that CBN might be effective as a sedative. However, because of the trial’s small sample size and age, its results were promising but inconclusive.

Similar findings were found in a 1995 mouse study that concluded synthetic CBN lengthened mice’s sleep periods. CBN is widely regarded as a powerful sedative based on the results of these studies, which cannabis industry experts have widely accepted. Nevertheless, experts agree that further clinical trials and research are needed to reach any conclusive findings.

Why You Should Consider Offering CBN Products To Your Customers

Even though research is still being conducted concerning CBN’s potential as a sleep aid, the general public seems convinced that CBN can improve sleep, increasing sales of sleep-promoting products containing CBN. Additionally, some awareness has spread about research on CBN as a pain reliever. However, it is more desirable to use this compound alongside other cannabinoids due to the entourage effect.

And while the average buyer doesn’t fully grasp the potential benefits of CBN, CBD has become a household name in a relatively short time, with the entourage effect known to many CBD lovers. As a result, CBD’s value may be boosted in the eyes of consumers when combined with other cannabinoids, such as CBN extract.

What is CBN extract?

CBN extract is produced from cannabis flowers that contain a high level of cannabinoids, most notably the cannabinoid CBN. This bulk hemp ingredient is typically available in several forms, most notably distillate and isolate. CBN distillate and CBN isolate have potency levels ranging from 70-97% of total cannabinoids, and each extract type can be used in a wide range of products.

What is CBN distillate?

With CBN distillate, large amounts of CBN are present in a distilled cannabinoid extract. Even though CBN distillate is far more refined than crude extract, it retains all the terpenes, minor cannabinoids, and other beneficial compounds found naturally in hemp flowers. Due to this feature, CBN distillate is highly preferred for products such as gummies, tinctures, and vaping products.

CBN distillate typically has a honey-like texture and appearance, offering CBN concentrations up to 80%. Although traces of THC can be found in some CBN distillates, this extract can be further purified to yield no detectable amounts of THC.

What is CBN isolate?

CBN isolate is almost entirely composed of pure cannabinol molecules. Due to its high chemical purity of 97%+, CBN isolate is suited to formulate many different products, despite not being particularly useful in its raw form.

The beauty of CBN isolate lies in its superior compatibility with virtually any cannabinoid extract. The nature of this ingredient allows any product to be easily infused with CBN’s distinct and fascinating benefits.

Uses

It’s possible to use CBN distillate and isolate for many of the same purposes despite their differences. For example, in vape cartridges, distillate offers a fuller spectrum of effects, whereas CBN isolate is more suitable for complex formulations that are difficult to balance. Plus, since both forms of the extract can be formulated with undetectable levels of THC, both CBN isolate and distillate are acceptable under federal and various state regulations.

Need Product Ideas?

Examples of products that are suitable for the simplistic nature of CBN isolate include:

– Tablets
– Capsules
– Topicals

Product types that work well with the rich flavor of CBN distillate include:

– Gummies
– Vape cartridges
– Tinctures

In reality, any of the products listed above can include CBN extracts of any type. Your strategy will ultimately depend on your goal and your target audience. You can customize the design of your new CBN-infused sleep products by partnering with an experienced cannabinoid white labeller.

When Sourcing The Ideal CBN Extract, What Should I Look For?

What is the best form of CBN extract for your specific needs now that you know all the essential details about CBN distillate and isolate? Here are some crucial facts to consider.

Historically, cannabinoid isolates were sought after because they contained no THC. However, today, removing any traces of THC from distillate is just as easy, so it is no longer an advantage unique to isolate.

When it comes to today’s hemp products, the primary reason to avoid using CBN distillate is because it has the potential to unbalance existing formulations. For example, for a product that already contains cannabinoid distillates, adding more extracts might not be a good idea. Alternatively, you could use an isolate extract to incorporate CBN into the product.

Realistically, these are just a few factors to consider before selecting a cannabinoid extract, none less important than the other. The best way to design your hemp product line is with the help of a trusted hemp white-label company like GVB Biopharma.

Address your Customers’ Concerns with the Best CBN Extract

The data shows millions of Americans actively seek natural solutions to their sleep problems. We can help you get started if you’re interested in providing customers with a CBN option. Plus, when searching for an effective CBN isolate or distillate, there’s no time to play guessing games. Our team at GVB Biopharma understands the nuances between extracts and is here to help. As an industry leader, we know what it takes to custom-fit products to your desired specifications. With unrivaled expertise, our integrated approach ensures optimal results for each of your final products.

By partnering with GVB Biopharma, you can unlock the maximum potential benefits and make all the difference to your clients and your company. Let us help give you an edge up on the competition with the best CBN extracts designed to give your customers a well-deserved restful night’s sleep. Contact us for your consultation today!

CBN & sleep FAQs

1. Does CBN make you groggy the next day?

People who use CBN before bed do not usually report that this cannabinoid causes grogginess or tiredness the following morning. In general, it is rare for users to complain of grogginess after using any cannabinoid — these natural substances have very limited side effects and have a limited overall impact on the human body and nervous system.

2. Can I take CBN every night?

While there does not appear to be any particular indication that taking CBN on a nightly basis poses any dangers to the average person, that’s the type of question for medical doctors and researchers — not cannabinoid producers. If you take CBN every night and you are worried about developing side effects, ask a doctor for their expert opinion.

3. Is CBN better than melatonin?

It doesn’t make sense to directly compare CBN and melatonin, but it’s true that CBN may have benefits that melatonin lacks while also making up for some of melatonin’s detriments. Melatonin, for instance, is a natural hormone, and nobody knows how introducing this hormone might disrupt melatonin already produced by the brain. The brain doesn’t produce CBN, though, eliminating this particular potential for conflict.

4. What are the side effects of CBN?

People who use CBN don’t usually note any side effects. If any side effects are reported, they almost always consist of excessive sleepiness or mild digestive disturbance. It’s possible that future research may unveil some previously unknown dangers of cannabinoids, but at present, these substances appear to be almost entirely benign.

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33. 17. Wong, H., & Cairns, B. E. (2019). Cannabidiol, cannabinol and their combinations act as peripheral analgesics in a rat model of myofascial pain. Archives of oral biology, 104, 33–39.
35. 18. Takahashi, R. N., & Karniol, I. G. (1975). Pharmacologic interaction between cannabinol and delta9-tetrahydrocannabinol. Psychopharmacologia, 41(3), 277–284.
37. 19. Karniol, I. G., Shirakawa, I., Takahashi, R. N., Knobel, E., & Musty, R. E. (1975). Effects of delta9-tetrahydrocannabinol and cannabinol in man. Pharmacology, 13(6), 502–512.
39. 20. Yoshida, H., Usami, N., Ohishi, Y., Watanabe, K., Yamamoto, I., & Yoshimura, H. (1995). Synthesis and pharmacological effects in mice of halogenated cannabinol derivatives. Chemical & pharmaceutical bulletin, 43(2), 335–337.
41. 21. Δ9-Tetrahydrocannabinol and Cannabinol Activate Capsaicin-Sensitive Sensory Nerves via a CB1 and CB2 Cannabinoid Receptor-Independent Mechanism. Peter M. Zygmunt, David A. Andersson and Edward D. Högestätt Journal of Neuroscience 1 June 2002, 22 (11) 4720-4727; DOI:

Post-traumatic stress disorder (PTSD) is a condition that can interfere with a person’s ability to relax. Furthermore, this trauma-related disorder is difficult to treat with medications¹. CBD is a cannabinoid that many people find to be uniquely calming and soothing. As a result, it is natural to consider using CBD for PTSD, but is this approach to treating post-traumatic stress disorder backed by science?

In this guide, learn why CBD is theorized to be useful for PTSD, and discover recent scientific research that might back this position. CBD should certainly be researched further for its potential to help with PTSD — as you will see as we continue.

What is CBD?

Cannabidiol (CBD) is the most abundant non-intoxicating cannabinoid found in Cannabis sativa². While similar compounds like cannabigerol (CBG) and cannabinol (CBN) have also come to light recently, CBD is considerably popular over any cannabinoid aside from THC. It is the undisputed cornerstone of the online hemp market. In terms of effects, CBD will not cause any sort of euphoric, pleasureful high. It does, however, generally help you relax and research suggests that the use of CBD might be helpful to reduce symptoms of anxiety³. Since anxiety remains such a major target of CBD research, it was only a matter of time until this profoundly beneficial cannabinoid would be researched for PTSD as well.

What are the benefits of CBD?

Despite its notable lack of intoxicating effects, CBD nonetheless appears to exert a wide range of benefits in the human body. People who use CBD commonly report that it reduces their pain, helps them get to sleep at night, and alleviates their overall anxiety levels⁴. International researchers are hard at work exploring these claims, seeking to either discount or substantiate CBD’s apparent benefits in the furtherance of the science of natural health.

What is PTSD?

Post-traumatic stress disorder (PTSD) is a persistent set of negative emotions and behaviors centered around a past traumatic event or series of events. Often founded upon feelings of guilt or continued fear of danger, PTSD represents both a cognitive and neurochemical puzzle to clinicians, many of whom have been forced to classify cases of PTSD as “treatment-resistant.”¹

Along with depression and other mental conditions that appear to be treatment-resistant, PTSD has been extremely challenging for the medical community. With some people reporting improved symptoms after using CBD for PTSD, more attention is being paid to this simple, non-intoxicating cannabinoid and its incredible healing power⁵.

What are the symptoms of PTSD?

If you are managing symptoms of PTSD, it is common to no longer feel in control of your own mind and behaviors. Some patients experience vivid flashbacks in which it is like they are reliving the trauma once more.

For almost all PTSD patients, intrusive thoughts are common. Defined as uncontrolled and often damaging ideas and self-perceptions, intrusive thoughts continually plague PTSD patients throughout all hours of the day and night.

These thoughts and other symptoms make sleep or even just basic relaxation difficult for PTSD patients. It is understandable why scientists are so interested in the potential usefulness of CBD’s benefit palette against the unnecessary torment that accompanies  PTSD.

Research into CBD for PTSD

In the April 2019 edition of the Journal of Alternative Complementary Medicine, the results of a study conducted by Elms et. al. were published that revealed CBD as a substance that could potentially deliver relief from the symptoms of PTSD.6 The study included 11 subjects, but even this small set of data is enough to draw some initial conclusions about the actual usefulness of administering CBD for PTSD in a clinical setting.

The subjects were all patients at a psychiatry clinic that also received routine psychiatric care during the course of the study. At the end of the eight-week study, 91% (or 10) of the 11 patients reported improvements in their PTSD symptoms after using CBD. Using the PTSD Checklist provided with the DSM-5, the facilitators of the study calculated an overall 28% decrease in PTSD symptom severity among the patients.

The authors of the study concluded that orally administering CBD over the eight-week window “was associated with PTSD symptom reduction in adults with PTSD”. Perhaps most interestingly, the authors go on to note that “CBD also appeared to offer relief in a subset of patients who reported frequent nightmares as a symptom of their PTSD”. These findings line up with academic and anecdotal evidence regarding the sleep-impacting effects of CBD.

Is CBD useful for PTSD?

The study we examined above is hardly the only piece of published research pertaining to CBD and PTSD. A handful of clinical trials into using CBD for PTSD have been initiated in the United States, for instance, and all signs point to this research accelerating in recent years.

Across the medical research discipline, an evolving sense of importance is being placed on conditions like PTSD for which we currently have no truly effective treatments. Whether it is psychedelics or cannabinoids, scientists and medical institutions are eager to find treatments for affective and stressor-based disorders that actually work without causing considerable side effects. We will know more about CBD’s usefulness for PTSD as this research continues.

The bottom line: Should CBD be used for PTSD?

It certainly appears that CBD should continue being seriously examined as a potential treatment for PTSD. While initial research directly into the usefulness of CBD for PTSD is certainly intriguing, what’s even more promising is the overall impressiveness of CBD’s apparent usefulness for mental health. From anxiety to depression to PTSD, people swear by CBD, and it’s about time we discovered exactly why.

CBD PTSD FAQs

1. How do you calm down when you have PTSD?

Some of the most basic ways that people calm down when they are feeling the symptoms of PTSD include deep breathing and visualizing calm or soothing environments or images. Therapists may ask people with PTSD to try additional techniques when symptoms occur, but ultimately, the most valid approach is gently soothing the underlying emotions that support PTSD. This is a complex process that no single substance can facilitate on its own.

2. What strain of CBD is best for pain?

No one is quite sure if there is a particular strain of CBD-rich hemp flower that is better for pain than others. If CBD is good for pain overall, though, the strain with the highest concentration of CBD would most likely be the most effective in that regard. At the same time, cannabis is a massively complex plant that we are only beginning to understand — perhaps some combination of cannabinoids and terpenes might be more effective than any one cannabinoid alone.

3. Does CBD help with feeling overwhelmed?

Some people feel that taking CBD can help them relax when they are overwhelmed. Most CBD products take a while to kick in, however, so expecting immediate relief from feelings of overwhelm might be a bit unreasonable.

4. What kind of CBD is best for severe anxiety?

If you suffer from severe or acute onset of anxiety, you’ll want to use a form of CBD that kicks in quickly. CBD tinctures, for instance, absorb in your mouth before swallowing, potentially allowing faster activation times. Ask your doctor if you have any further questions about treating severe anxiety.

Sources

1. 1. Fonzo, G. A., Federchenco, V., & Lara, A. (2020). Predicting and managing treatment non-response in posttraumatic stress disorder. Current Treatment Options in Psychiatry, 7(2), 70-87, Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748158/
2. 2. Protti, M., Brighenti, V., Battaglia, M. R., Anceschi, L., Pellati, F., & Mercolini, L. (2019). Cannabinoids from Cannabis sativa L.: a new tool based on HPLC–DAD–MS/MS for a rational use in medicinal chemistry. ACS Medicinal Chemistry Letters, 10(4), 539-544.Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466817/
3. 3. Skelley, J. W., Deas, C. M., Curren, Z., & Ennis, J. (2020). Use of cannabidiol in anxiety and anxiety-related disorders. Journal of the American Pharmacists Association, 60(1), 253-261. Retrieved from https://www.sciencedirect.com/science/article/abs/pii/S154431911930514X
4. 4. Haack, M., Simpson, N., Sethna, N., Kaur, S., & Mullington, J. (2020). Sleep deficiency and chronic pain: potential underlying mechanisms and clinical implications. Neuropsychopharmacology, 45(1), 205-216. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879497/
5. 5. Bitencourt, R. M., & Takahashi, R. N. (2018). Cannabidiol as a therapeutic alternative for post-traumatic stress disorder: From bench research to confirmation in human trials. Frontiers in Neuroscience, 502. Retrieved from https://www.frontiersin.org/articles/10.3389/fnins.2018.00502/full?_ga=2.28443646.376123967.1620850395-746040275.1604383068
6. 6. Elms, L., Shannon, S., Hughes, S., & Lewis, N. (2019, April). Cannabidiol in the Treatment of Post-Traumatic Stress Disorder: A Case Series. The Journal of Alternative and Complementary Medicine, 25(4), 392–397. Retrieved from https://doi.org/10.1089/acm.2018.0437

With some sources boasting that it is 100 times more effective than CBD, it’s no wonder that the hydrogenated cannabinoid, H4CBD, has been getting a lot of attention recently.(1) In this guide, we’ll examine H4CBD from every possible angle and explain how to find the best H4CBD products available on the market. Dive into our in-depth guide to H4CBD: what It is, what it does, and how it compares to CBD.

What is H4CBD?

Hexahydrocannabidiol (H4CBD) is a synthesized cannabinoid, created by converting the two carbon-carbon double bonds in the limonene part of CBD to single bonds via the addition of four hydrogen atoms. This process, known as hydrogenation, is very similar to that used to make margarine from vegetable oil.

What does H4CBD do?

The exact properties of H4CBD remain largely unknown, The limited information available on this cannabinoid indicates that it has a considerably higher affinity for your brain’s CB1 neuroreceptors than conventional CBD. Since CBD normally does not have any direct affinity for CB1 receptors, it is unclear what to make of this data. Nonetheless, people who use H4CBD generally report that it feels like CBD, but with considerably higher psychoactivity.

Is H4CBD the same thing as CBD?

No. H4CBD and conventional CBD share many similarities, but they are not exactly the same molecule. These two cannabinoids offer completely different experienced effects. Also, from its chemical structure down to its method of procurement, CBD is fundamentally different from H4CBD.

H4CBD vs. CBD

How exactly do CBD and H4CBD compare when examined side-by-side? Discover the differences and similarities between these cannabinoids across the seven categories below:

Source

Both CBD and H4CBD come from hemp. While CBD is a direct hemp derivative, H4CBD is artificially modified, via hydrogenation, to reach its final form.

As a result, H4CBD must technically be considered a synthetic cannabinoid, even if it is only as synthetic as margarine. It’s technically possible to synthesize CBD as well. However, this cannabinoid is so abundant in hemp that there is no incentive to produce it synthetically.

Structure

H4CBD has been structurally altered to be slightly different from CBD. To transform CBD to H4CBD, four additional hydrogen atoms have been added to the limonene head of the molecule, replacing two carbon-carbon double bonds with single bonds, and, thereby, changing its shape and inherent properties.

Effects

Due to the results of a single study from 2006, there’s widespread speculation that H4CBD may be as much as 100 times more potent than CBD — at least in certain ways. The study in question found that hydrogenated forms of CBD showed surprisingly high affinity for the brain’s CB1 neuroreceptors.¹

The level of affinity was nowhere near as high as is observed in the case of THC, but it was, nonetheless, notable. While a 2017 research review echoed this opinion, no new studies into the bioactive or psychoactive properties of H4CBD have been conducted recently.²

Anecdotally, H4CBD users have noted that using this cannabinoid feels something like taking a 2:1 CBD:THC product. The familiar, non-intoxicating effects of CBD are still dominant. There’s also a slight sense of intoxication that might help take the edge off or make the effects of CBD more enjoyable.

Potency

Overall, it would be safe to say that H4CBD might offer something in the range of three times the potency of CBD. It’s been claimed that H4CBD offers 100 times the potency of normal CBD. Even if that’s the case, CBD’s potency at your CB1 receptors is negligible, at best.

In mathematical terms, if you take a tiny number and multiply it by a hundred, you’re still left with a tiny sum. The potentially increased activity of H4CBD at your CB1 receptors certainly appears to be worth further investigation. At present, it is unknown whether  H4CBD is “100 times more effective” than CBD in every area that CBD affects.

Legality

The legality of cannabinoids — both synthesized and natural — is currently a matter of considerable dispute. Overall, cannabinoids that are not delta-9 tetrahydrocannabinol are considered industrial hemp under the 2018 Farm Bill. Beyond this, the FDA has yet to produce meaningful regulations to help guide the rapidly growing online cannabinoid industry. Continue checking this space for updates as they emerge.

Availability

Between the two, CBD is currently by far the more widely available cannabinoid. Demand for H4CBD is rapidly growing and will naturally lead to the development of a wider array of products. Already, high-quality H4CBD distillates, isolates, and finished products are starting to appear online, heralding the beginning of a brand-new hemp renaissance.

How to choose the best H4CBD source

With H4CBD being such a new cannabinoid, it’s essential that you choose a source of H4CBD products that has an established reputation for excellence. The right H4CBD manufacturer will be well-established and have an excellent reputation for reliability, purity, and customer service.

Their facilities will be professionally certified and fully compliant with the lastest regulations. You should be offered a choice between pre-formulated and custom-formulated products. The best H4CBD company for your needs will assign a customer support specialist to guide you through the entire process to ensure your complete satisfaction, from start to finish.v

The bottom line: Is H4CBD better than CBD?

Scientists have known about H4CBD since the 1940s, but it’s only recently that this hydrogenated form of CBD entered the spotlight.³ As CBD has reached heights of popularity no one previously thought possible, demand for alternatives that might offer even-better benefits has arisen along with it.³

Is H4CBD truly the dark horse that will supplant CBD as the dominant option on the market? Since CBD is so beloved and abundant, it’s unlikely. If it’s true that H4CBD is more potent than conventional CBD in certain ways, it will certainly carve out a niche that requires new products.

H4CBD and CBD may have distinct differences, but consider their collective benefits: CBD could be the traditional, lower-strength, all-natural option while H4CBD would serve as the slightly-tweaked, higher-potency alternative. As the modern cannabinoid pharmacopeia continues to evolve, both CBD and H4CBD will certainly play pivotal roles.

H4CBD FAQs

1. What are hydrogenated cannabinoids?

A hydrogenated cannabinoid is a cannabinoid that has been subjected to hydrogenation, a process that adds hydrogen atoms to molecules. Many cannabinoids can be hydrogenated, and in most cases, it’s possible to hydrogenate each cannabinoid with different quantities of hydrogen atoms at different molecular locations. Every hydrogenated cannabinoid has unique properties. But in most cases, the chemical hydrogenation of a cannabinoid typically increases its potency.

2. Is H4CBD synthetic?

Yes, H4CBD is technically synthetic. Keep in mind that this hydrogenated cannabinoid has not been artificially constructed from scratch or combined with any complicated substances. Nonetheless, any alteration in a natural compound is considered a synthetic form of the original. Also, synthesized versions of substances almost always have new and unique properties.

3. Is H4CBD 100 times stronger than CBD?

The claim that H4CBD is 100 times stronger than conventional CBD is more hype than it is fact. Based on a single, unreplicated study from more than 15 years ago, scientists now speculate that H4CBD may demonstrate remarkably increased activity compared to CBD — but at the nervous system’s CB1 receptors, not the main targets of conventional CBD.

Normally, CBD has very little affinity for CB1 and may even reduce its activity. While CBD acts to potentiate the effects of endogenous cannabinoids, it acts to oppose THC’s interaction with CB1. It is a modulator of THC’s psychoactive effects. As a result of hydrogenation, H4CBD acquires a measurable affinity for CB1, making the synthetic cannabinoid more psychoactive.

4. Does H4CBD get you high?

It wouldn’t be quite accurate to say that H4CBD gets you high. Still, this cannabinoid certainly doesn’t provide the effects you usually associate with CBD, either. Based on limited preliminary research and anecdotal testimony, it appears that taking H4CBD feels like taking a big dose of CBD alongside a small dose of THC. As anyone who has ever combined the two cannabinoids knows, CBD has a tendency to drown out THC without completely eliminating its effects.

5. Is H4CBD the same thing as HHC?

No, H4CBD and HHC are different. Based on their origins, it’s natural to get the two cannabinoids confused. Just as H4CBD is a hydrogenated form of CBD, HHC is a hydrogenated form of THC. While H4CBD is believed to show greater activity at the CB1 receptors than CBD, HHC is generally believed to actually be somewhat weaker than conventional THC. Both examples show how hydrogenation can make modulate the potency of a substance.

6. Are there strains with H4CBD?

No, there are no strains of cannabis or hemp containing H4CBD because this cannabinoid is not naturally occurring. Since it is not possible to extract natural H4CBD, this cannabinoid can only be made artificially.

7. What is the best type of H4CBD product?

So far, users generally seem to prefer H4CBD vapes and gummies. Over time, we expect H4CBD capsules, tablets, and, even, topicals to also come into high demand. Whichever type of product you choose, H4CBD products should contain simple ingredients and be accompanied by thorough lab reports.

8. What are some common H4CBD effects?

Based on what little we know so far, it appears that H4CBD has roughly the same effects as CBD. Some evidence suggests that this synthetic derivative of CBD may be more effective at certain neuroreceptors. These neuroreceptors are not, however, commonly associated with the effects of CBD. Due to a continuing lack of research, not enough is known about H4CBD to say anything definitive regarding its effects.

9. What is H4CBD distillate?

H4CBD distillate consists of H4CBD combined with a “denatured” hemp distillate, from which other cannabinoids have been removed. Rare cannabinoids like H4CBD are often offered in distillate form since it is easy to combine a distillate base with practically any isolated cannabinoid.

H4CBD must be produced as a derivative of a natural hemp cannabinoid, making H4CBD distillate an inherently synthetic product. Even though its dominant cannabinoid is synthetic, H4CBD distillate still looks like you’d expect a distillate to look — honey-colored, viscous, and translucent.

10. What is the difference between CBD and H4CBD?

The primary difference between CBD and H4CBD is that CBD is natural while H4CBD is not. The dissimilarities don’t end there. It’s also an indisputable fact that we know far less about H4CBD than we do about conventional CBD — though there’s still plenty left to learn about both cannabinoids.

11. H4CBD gummies vs. H4CBD tinctures

Out of the two products, H4CBD tinctures are more likely to be simple and natural while H4CBD gummies might taste better or be easier to use. All new cannabinoids go through a transitional, scale-up period before many high-quality product sources become readily available.

As a result, it’s prudent to do plenty of research into how H4CBD gummies or tinctures are made before making any type of commitment. The H4CBD market is just beginning to emerge. It may take some time until competition and production systems drive product quality up to standard acceptable levels.

References

1. 1. Ben-Shabat, S., Hanuš, L. O., Katzavian, G., & Gallily, R. (2006, January 6). New Cannabidiol Derivatives: Synthesis, Binding to Cannabinoid Receptor, and Evaluation of Their Antiinflammatory Activity. Journal of Medicinal Chemistry, 49(3), 1113–1117. Retrieved from https://pubs.acs.org/doi/10.1021/jm050709m
2. 2. Morales, P., Reggio, P. H., & Jagerovic, N. (2017, June 28). An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol. Frontiers in Pharmacology, 8. Retrieved from https://www.frontiersin.org/articles/10.3389/fphar.2017.00422/full
3. 3. Jacob, A., & Todd, A. R. (1940). 119. Cannabis indica. Part II. Isolation of cannabidiol from Egyptian hashish. Observations on the structure of cannabinol. Journal of the Chemical Society (Resumed), 649. Retrieved from https://pubs.rsc.org/en/content/articlelanding/1940/JR/jr9400000649
4. 4. Laprairie, R. B., Bagher, A. M., Kelly, M. E. M., & Denovan-Wright, E. M. (2015, October). Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor. British Journal of Pharmacology, 172(20), 4790–4805. Retrieved from https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.13250

Cannabis has been cultivated and revered for thousands of years. Nonetheless, it is only during the last century that science has begun to unveil its true complexity. As recently as the mid-20th century, our misconceptions, regarding the chemical structure of cannabis components, remained considerable. In fact, it’s only in the last few decades that the taxonomy of the hemp plant and its derivatives has become truly comprehensive.

For instance, scientists only recently started looking closely at rare, minor cannabinoids, like cannabimovone (CBM). Only present in rare varieties of hemp and in very small quantities, CBM has been incredibly hard to obtain. This is frustrating because CBM may offer exciting benefits for certain medical conditions.

Now, for the first time ever, CBM products are finally appearing on the market. What does CBM do and why should you use it? Find the answers in this thorough introduction to cannabimovone.

When was CBM discovered?

Cananbimovone was discovered by accident in 2010¹ in a regional Italian hemp variant, called Carmagnola. Later, another Italian research team discovered the “super-cannabinoids” THCP and CBDP² in Carmagnola, fueling further interest in this peculiar hemp strain.

In 2020, a team led by Fabio Arturo Iannotti submitted a study to Molecules³ that would gain international attention for CBM. In this publication, the research team found evidence that CBM may act as a PPARγ(Peroxisome proliferator-activated receptor gamma or PPARG) agonist – a type of therapeutic compound that stimulates PPARγ and is currently used to treat metabolic syndrome. If further research supports this evidence, CBM could prove useful in metabolic regulation and have a massive impact on the worldwide cannabinoid economy.

Is CBM a natural cannabinoid?

Yes, CBM is a natural cannabinoid, found in certain strains of Cannabis sativa. In nature, however, cannabimovone is available in quantities too small to be economically extracted. As a result, this cannabinoid is usually synthetically derived from CBD rather than extracted from hemp.

Where does CBM come from?

CBM occurs in some varieties of hemp, aside from Carmagnola. Most CBM is synthesized from CBD, making it similar to many other cannabinoids, like CBN and CBG. Because it has been synthesized, CBM is usually offered in its isolated form. However, it can be added to broad-spectrum or full-spectrum hemp extracts as well.

What does CBM do?

CBM is a very new cannabinoid, so it’s hard to speculate on all its potential effects. Based on initial evidence, it appears CBM should be investigated in more detail for its possible benefits against diabetes, metabolic disorders, and other conditions caused by faulty metabolic signaling.⁴

Scientists have been investigating the potential benefits of cannabinoids for conditions ameliorated by increased PPAR signaling since at least 2007⁴. Research into this subject has accumulated over the years and will likely accelerate in the wake of recent discoveries, regarding CBM.

How does CBM work?

The regulation of energy metabolism in the human body is heavily influenced by two receptors, located in the nucleus of all our cells: PPARα (PPAR-alpha) and PPARγ (PPAR-gamma). PPARα stimulates genes that increase fat metabolism, modulate insulin secretion, and decrease vascular inflammation. In essence, it helps to prevent diabetes and the development of “fatty liver disease.” PPARγ complements PPARα by regulating the formation and metabolism of fat cells, increasing sensitivity to insulin, and enhancing glucose metabolism.  Together, these molecules help to regulate the body’s energy budget.

Poor insulin regulation leads to metabolic disorders, like diabetes and liver steatosis. By activating PPARγ receptors, cannabinoids like⁵ CBM might both promote proper cell growth and hormonal regulation, helping people with diabetes and similar conditions. However, research on the potential benefits of CBM is still ongoing.

What are the benefits of CBM?

As a PPARγ agonist, CBM is ideal since it can be made abundantly and inexpensively from CBD. Its benign pharmacological activity may provide an improved side effect profile compared to other potent PPARγ agonists.

Scientists have known about and targeted the body’s PPAR receptors in attempts to pharmacologically treat diabetes and other metabolic disorders over the years. There are even a few FDA-approved PPARγ agonist drugs on the market. However, consumers have shied away from this drug class due to certain unpleasant side effects (e.g., weight gain and fluid retention).

Cannabinoids are generally known as safe, making CBM a worthy target of research. If proven to be a safer source of PPARγ agonist activity than conventional pharmaceuticals, CBM could become a hotly desired commodity within the nutraceutical sector.

Is CBM legal?

Under the 2018 Farm Bill, cannabinoids other than delta 9 THC are generally considered “industrial hemp.” We are not aware of any efforts on the state or federal level to regulate CBM specifically. So, in the absence of specific legal prohibitions, it is reasonable to assume that CBM has roughly the same legal status as similar hemp-derived cannabinoids.

Can you buy CBM online?

Yes, it is now becoming possible to buy CBM online for the first time. Producers have recently learned how to produce this ultra-rare cannabinoid in scalable, commercial quantities. They are ready to put CBM products on the shelves, just as consumers are discovering the potential benefits of this cannabinoid.

At present, CBM is usually only available online in bulk quantities. A variety of different hemp extract types, containing CBM, may be available. Isolated CBM may also be combined and sold with broad-spectrum or full-spectrum hemp extracts, containing other cannabinoids.

Summary: Should you try CBM?

More and more, cannabis is amazing researchers with its vast list of potential cannabinoid-derived benefits. Each cannabinoid contributes its own unique health-promoting effects that can work together with others to alleviate certain ailments.

Consumers are starting to view CBM as yet another strand in that web of cannabinoid wellness. While CBM is still too new for us to make any firm statements about it, it’s also true that what we know about cannabis already tells us that any future discoveries, regarding CBM, are unlikely to be disappointing.

Already, cannabinoids have revolutionized fields of medicine in ways nobody ever expected. CBM could well be the next chapter in this saga of natural hemp wellness. It’s now time to explore everything this new and promising cannabinoid can do.

CBM FAQs

Learn more about CBM, its benefits, and what it can do in the FAQ section below:

1. Is CBM the same as CBN?

No, despite being known by acronyms with final letters that are right next to each other in the alphabet, CBM and CBN are, in fact, quite different. Cannabinol (CBN) is a natural metabolite of THC, but it isn’t a primary product of the cannabis flower.

CBM, however, is its very own, naturally-produced cannabinoid — it isn’t a metabolite of anything. CBN and CBM also appear to have very different effects, though there’s still a lot we need to learn about both cannabinoids.

2. Is cannabimovone related to cannabicitran (CBT)?

No, cannabimovone and cannabicitran aren’t directly related. However, both substances are considered to be rare, minor cannabinoids. Discovered in the 1970s, CBT has been on the radar of international researchers for much longer than CBM. Even so, we still know just about as little about CBT as we do about CBM, CBE, or any of the other minor cannabinoids that are now becoming available online.

3. Is cannabimovone an HHC metabolite?

No, cannabimovone is not related to HHC or any other cannabinoids in the THC family. Instead, cannabimovone is structurally similar to CBD, although these two cannabinoids are not identical. Like CBD, CBM appears to serve a unique purpose that separates it from other hemp compounds.

4. Does CBM affect your cannabinoid receptors?

No, initial research into CBM does not indicate that this cannabinoid has any significant impact on your conventional CB1 and CB2 cannabinoid receptors. Instead, this cannabinoid appears to primarily target your PPARγ receptors, which are critically important for combating insulin resistance.

5. What kinds of CBM products are there?

Right now, cannabimovone products are usually only available online in bulk quantities. From select producers, you can buy CBM either in bulk ingredient form or preformulated into finished products, like tinctures, capsules, and gummies. The sky’s the limit when it comes to this relatively untapped component of the online hemp market.

6. Can you use CBM with other cannabinoids?

Yes, there appears to be no reason to avoid using CBM in conjunction with other cannabinoids. Generally, cannabinoids are observed to synergize with each other, so using CBM with other cannabinoids may be beneficial. Nonetheless, keep in mind that we still know very little about the overall safety of CBM.

7. Is CBM the same as HHC?

No, cannabimovone is a different cannabinoid entirely from hexahydrocannabinol, also known as HHC. The differences between these two compounds are many:

– HHC is easy to create and already abundant

– CBM is practically unheard of and almost nonexistent

– HHC has potent intoxicating properties

– CBM does not appear to be intoxicating at all

So many cannabinoids have recently become popular that it can be a challenge to tell them apart. Learning the differences between the new cannabinoids that have flooded the market is key to choosing the right ones for your needs.

8. Is cannabimovone synthetic?

No, cannabimovone is not inherently synthetic — it naturally occurs in certain strains of  Cannabis sativa—so it’s a natural compound. Since CBM is only available in very small quantities in nature,  all of the CBM currently available online has been synthesized from another cannabinoid. Chemically modifying one cannabinoid to produce another isn’t usually dangerous, but it does make the resulting substance, technically, synthetic.

9. Where can I buy CBM?

At present, CBM is only available for research purposes from large pharmaceutical manufacturers. The type of CBM sold by these manufacturers is chemically isolated and not suitable for consumption. Expect the world’s first CBM products to enter the market around the same time that shoppers start becoming aware of the benefits of this obscure cannabinoid.

10. Is CBM safe?

There is no evidence, indicating that CBM poses any particular dangers to the average user. Most cannabinoids, aside from THC, have been determined to have very little if any significant side effects. It’s very unlikely that CBM will break this trend. Be sure to only use CBM products that are designed for human consumption to avoid ingesting laboratory contaminants.

Sources

1. 1. Taglialatela-Scafati, O., Pagani, A., Scala, F., de Petrocellis, L., di Marzo, V., Grassi, G., & Appendino, G. (2010). Cannabimovone, a cannabinoid with a rearranged terpenoid skeleton from hemp. European Journal of Organic Chemistry, (11), 2067–2072. Retrieved from https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejoc.200901464
2. 2. Citti, C., Linciano, P., Russo, F., Luongo, L., Iannotta, M., Maione, S., Laganà, A., Capriotti, A. L., Forni, F., Vandelli, M. A., Gigli, G., & Cannazza, G. (2019). A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol: Δ9-Tetrahydrocannabiphorol. Scientific Reports, 9(1). Retrieved from https://www.nature.com/articles/s41598-019-56785-1
3. 3. Iannotti, F. A., de Maio, F., Panza, E., Appendino, G., Taglialatela-Scafati, O., de Petrocellis, L., Amodeo, P., & Vitale, R. M. (2020). Identification and characterization of Cannabimovone, a cannabinoid from Cannabis sativa, as a novel PPARγ agonist via a combined computational and functional study. Molecules, 25(5), 1119. Retrieved from https://www.mdpi.com/1420-3049/25/5/1119
4. 4. Sun, Y., & Bennett, A. (2007). Cannabinoids: A new group of agonists of PPARs. PPAR Research. Retrieved from https://www.hindawi.com/journals/ppar/2007/023513/
5. 5. O’Sullivan, S. E. (2016). An update on PPAR activation by cannabinoids. British journal of pharmacology, 173(12), 1899-1910. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882496/

The cannabinoid market is nothing like it was a decade ago. In 2012, the very first CBD products started to become available, and it wasn’t until 2018 that the CBD industry received an official nod from the US federal government.

On the other hand, the cosmetics industry has stayed relatively stable over the last 10 years. It hasn’t grown considerably, but it hasn’t declined at all. Interest in cosmetic products is the same as it always has been, but the cosmetics people are using are very different than they once were.

In this guide, learn the current size of the US cosmetics industry and the exact ways it has evolved in recent years. Then, discover the best hemp cannabinoids currently on the market that you can add to cosmetic products.

What is the current size of the US cosmetics industry?

According to a recent report from market analytics firm IBISWorld¹, the US cosmetics market is expected to be valued at just over $49 billion in 2022, a 1.5% increase over 2021’s total. As a result, cosmetics is among the larger consumer products industries, but it doesn’t show much room for overall growth.

Has the cosmetics market grown in recent years?

No, the US cosmetics market has not grown considerably over the last decade. The best year for cosmetics between 2012 and 2022 was 2015 at $55.4bn, and the worst year was 2020 at $44.7bn. As you can see, the cosmetics market has floated around the $50 billion annual revenue mark for quite some time.

How has the cosmetics market changed over the last decade?

The cosmetics market may not have gotten any larger or smaller over the last 10 years, but that doesn’t mean it hasn’t changed. Considerable shake-ups have taken place under the hood of the cosmetics industry, and outdated products are being phased out while newer ingredients are being added to the market.

Overall market size has stayed steady

If you look at market conditions closely, it’s surprising that the cosmetics industry hasn’t diminished from its stable $50 billion yearly revenue. During the last decade, the profound dangers of dozens of cosmetic substances² have come to light, and thousands of products have been taken off the shelves permanently.

To make up for the parabens, PFAs, methylene glycol, and other substances that are thankfully no longer present in cosmetics, new ingredients must have emerged within the cosmetics market or else the entire industry would have collapsed. As the raw data suggest, cosmetics manufacturers have ditched synthetic toxins and have started embracing natural healing substances instead.

Natural substances are on the rise

Whether it’s aloe vera, vitamin C, hyaluronic acid, essential oils, or even CBD, cosmetic products are now packed with natural substances believed to be even more effective than the dangerous ingredients they in some cases replaced. Access to the internet and its treasure trove of publicly accessible medical studies has given consumers the tools they need to make their own health and beauty decisions, and they’re starting to recognize the incredible potential present in nature’s unaltered bounty.

The population is aging

The US Census bureau indicates that by 2060, more than a quarter of Americans will be over 65³, an unprecedented “aging-out” of the US population that will have a profound impact on the cosmetics market. Interest in anti-aging compounds that don’t have any side effects will rise, and as budgets become constrained to Medicare and Medicaid, affordability will also be a prime concern.

Can you use cannabinoids in cosmetics?

Yes, you can certainly use cannabinoids in cosmetics, and the practice has become quite widespread. Cannabinoids that are commonly used in cosmetics include CBD, CBG, CBC, and CBN. The latter cannabinoid isn’t used all that commonly, but CBD, CBG, and CBC have all been investigated for their usefulness against conditions commonly treated topically.

What do cannabinoids do in cosmetics?

Consumers don’t just want cosmetics that make them look better anymore. They want cosmetics that actually make them better — in other words, cosmetics with healing properties. That’s where cannabinoids come into the picture.

Most substances present in Cannabis sativa flowers are believed to have at least some anti-inflammatory or antioxidant utility. Since oxidative stress is now widely known to be the primary cause of skin aging, antioxidants have become incredibly popular in cosmetic products over recent years. Anti-inflammatory substances, in addition, can often directly reduce the redness of skin conditions like acne, eczema, or rosacea.

Benefits of adding cannabinoids to cosmetics

As far as cosmetic ingredients go, cannabinoids are practically ideal. Cannabinoid extracts are easy to add to many different cosmetic formulations including lip balms, serums, and moisturizers, and cannabinoids are believed to have an overall positive effect on your skin health without causing considerable side effects.

“CBD” has become a buzzword within the online natural health community, so the inclusion of this cannabinoid often adds value to cosmetic products in and of itself. This effect has expanded recently to also apply to CBG and CBC, which consumers are starting to recognize as potentially being just as, or potentially even more useful in cosmetics as CBD.

What are the best cannabinoids to add to cosmetics?

If you don’t know which cannabinoids to include in your products, learn more about the most popular options below:

1. CBD

The most popular and well-known hemp cannabinoid by far, cannabidiol (CBD) has been investigated extensively⁴ for its potential antioxidant and anti-inflammatory benefits, and consumers generally believe it is at least somewhat useful in this regard. CBD should not have any noticeable psychoactive effects when applied topically in the form of a cosmetic, but it will provide benefits at the site of application for 3-6 hours.

2. CBG

Cannabigerol (CBG) has received a lot of attention recently due to research into its usefulness for bacterial infections⁵. Resultantly, CBG has become a red-hot popular substance in hand creams and other cosmetics designed to prevent transmissible illness. CBG is also rapidly gaining popularity in anti-acne topicals.

3. CBC

Cannabichromene (CBC) is still considered to be a rare cannabinoid, but consumers are catching onto research into this cannabinoid’s activity at your TRP receptors⁶, the primary neuroreceptors involved in inflammation. Manufacturers are accommodating this trend by infusing anti-inflammatory cosmetics with CBC.

4. CBN

The THC metabolite cannabinol (CBN) is currently the subject of a clinical trial⁷ into its potential wound-healing attributes. At present, CBN remains very rare in topical products, but hemp brands would be wise to watch this emerging space within the cannabinoid topical industry closely.

5. CBDa, CBGa, CBDV, etc.

CBD, CBG, CBC, and CBN are hardly the limit of the cannabinoids present in Cannabis sativa. Most cannabinoids, for instance, also have carboxylic acid forms with unique properties. CBDa isn’t the same chemically as CBD, for instance, and CBDV is another unique compound in itself. Over the years, the cannabinoid cosmetic industry will widen to accommodate even more of these natural healing substances.

Which cannabinoid-infused cosmetics products are the most popular?

Not sure which product types are best for infusing CBD, CBG, or CBC into? Here are the most popular types of cannabinoid cosmetics currently on the market.

Lip balms

Simple, affordable, and easy to produce, cannabinoid lip balms have been on the market longer than practically any other type of cannabinoid cosmetic. In this day and age, it can be a struggle to make a cannabinoid lip balm product stand out, but the addition of new cannabinoids to your ingredient pool allows new opportunities for diversification.

Moisturizers

It’s relatively easy to add CBD, CBG, or CBC to moisturizers, and there’s a general consensus among consumers that these substances improve moisturization via the reduction of inflammation and oxidative stress. Cannabinoids are common in both face moisturizers and products designed for your body and hands.

Serums

Relatively new to the market are serums: light, water-based cosmetics that you usually apply to your face. Designed to deliver beneficial substances deep into your skin with as few ingredients as possible, serums can be marketed at high prices as long as they feature formulations that are deservingly high-quality. Consumers generally view the inclusion of cannabinoids in serums as a value addition.

Body lotions and oils

Cannabinoid body lotions and oils are essentially no different than cannabinoid tinctures, which makes them affordable and easy to make. Used for massage, moisturization, and other purposes, adding cannabinoids to body oils is believed to make these products more therapeutic.

How to add cannabinoids to your cosmetics line

Using cannabinoids in cosmetics is no longer a risky move. Consumers have had enough time to accept the benefits of these essentially risk-free compounds, and demand for cannabinoid-infused cosmetics continues to rise.

Ten years from now, it’s likely that the US cosmetics market will be roughly the same overall size that it is today. Cannabinoid-infused cosmetics will take up a much larger share of the market, however, and every new cannabinoid cosmetic product launch will serve as a stepping stone along the way.

Pick the right cannabinoid or cannabinoids, choose a formulation type, and find a manufacturer. Within no time, you’ll have claimed your place within one of the biggest cosmetics industry shake-ups of the century.

Cannabinoids & cosmetics FAQs

Which cannabinoid is best for skin?

So far, it’s looking like CBG will shape up to be the superstar of the cannabinoid skincare industry. There’s a lot we don’t know about all of the cannabinoids present in hemp, however, so it’s too soon to decide if one cannabinoid is truly better than all the rest at keeping your skin healthy.

Are cannabinoids absorbed through the skin?

Yes, cannabinoids are naturally absorbed through the skin, but they usually must be accompanied by some form of carrier to achieve ideal penetration. As a result, water-based cannabinoid topicals are often preferred over oil-based equivalents since using a water base allows topicals to absorb with greater efficacy — even if they contain oil-based ingredients.

Does CBD work in skincare?

CBD has not been approved as an ingredient in any skincare products, so we can’t provide any official data regarding its usefulness as a skincare substance. What we can say, however, is that CBD users who apply this cannabinoid to their skin often report incredible results. According to users, these improvements could never have been accomplished with non-cannabinoid products.

Sources

1. 1. IBISWorld – Industry Market Research, Reports, and Statistics. (2022). IBISWorld. https://www.ibisworld.com/industry-statistics/market-size/cosmetic-beauty-products-manufacturing-united-states/
2. 2. Zanolli, L. (2019, July 2). Pretty hurts: are chemicals in beauty products making us ill? The Guardian. https://www.theguardian.com/us-news/2019/may/23/are-chemicals-in-beauty-products-making-us-ill
3. 3. Nasser, H. E. (2021, October 9). The U.S. Joins Other Countries With Large Aging Populations. Census.Gov. https://www.census.gov/library/stories/2018/03/graying-america.html
4. 4. Atalay, S., Jarocka-Karpowicz, I., & Skrzydlewska, E. (2019). Antioxidative and Anti-Inflammatory Properties of Cannabidiol. Antioxidants, 9(1), 21. https://doi.org/10.3390/antiox9010021
5. 5. Aqawi, M., Sionov, R. V., Gallily, R., Friedman, M., & Steinberg, D. (2021). Anti-Bacterial Properties of Cannabigerol Toward Streptococcus mutans. Frontiers in Microbiology, 12. https://doi.org/10.3389/fmicb.2021.656471
6. 6. Izzo, A. A., Capasso, R., Aviello, G., Borrelli, F., Romano, B., Piscitelli, F., Gallo, L., Capasso, F., Orlando, P., & di Marzo, V. (2012). Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice. British Journal of Pharmacology, 166(4), 1444–1460. https://doi.org/10.1111/j.1476-5381.2012.01879.x
7. 7. INM-755 (Cannabinol) Cream for Treatment of Epidermolysis Bullosa. (2022). US National Library of Medicine. https://clinicaltrials.gov/ct2/show/NCT04908215

For hundreds of years, pharmaceuticals have been understood to be substances that improve your health in some way. Nutraceuticals are the same thing except that they’re derived from natural sources instead of synthesized in a lab.

According to recent surveys, an increasing number of consumers are seeking health help from nutraceuticals, not pharmaceuticals. The nutraceutical industry is now worth tens of billions of dollars, and the popularity of nutraceuticals has synergized with an overall increase of interest in natural approaches to health.

What are nutraceuticals, exactly, and how are they changing the health industry? Find out everything you need to know about this class of natural health aids — including the details regarding their relationship with cannabinoids.

What are nutraceuticals?

Strictly speaking, a nutraceutical is a food that contains substances believed to improve your health. Nutraceuticals don’t have to come in the form of whole meals. It’s important to stipulate that nutraceuticals come from foods because pharmaceuticals usually don’t.

The term “nutraceutical” has generally evolved to encompass all naturally derived supplements believed to have health benefits. To denote this wider group of substances, the alternative term “bioceutical” is sometimes substituted.

How does the FDA define nutraceuticals?

The FDA generally uses the term “dietary supplement” instead of “nutriceutical.” While academic papers¹ insist that this federal regulatory agency acknowledges the existence of nutraceuticals, the FDA doesn’t have an official definition for them. Instead, nutraceuticals generally fall under the FDA’s definition of dietary supplements, which reads (in part): “[a] product (other than tobacco) in the form of a capsule, powder, softgel or gelcap intended to supplement the diet to enhance health.”

What is the difference between nutraceuticals and pharmaceuticals?

Nutraceuticals are derived from entirely natural sources, but pharmaceuticals can be produced using artificial means. The term “nutraceutical” also generally infers that a substance has nutritional value, but this isn’t always the case.

Since industry leaders started referring to natural supplements as nutraceuticals, our understanding of human health has developed quite a bit. It’s now recognized that hundreds of different natural substances might have health benefits — even those that don’t have any nutritional value.

What types of nutraceuticals are there?

Nutraceuticals are all alike in that they’re derived from natural sources that are often used for food, but the similarities end there. Some nutraceuticals — like the terpene limonene, for instance — can be directly derived from citrus fruits used for food. Others, however, come from yeast, mushrooms, or even rocks².

For the purpose of industry analysis, nutraceuticals are generally divided into three categories: dietary supplements, functional foods, and functional beverages. Put another way, the three main economic categories of nutraceuticals are products you swallow, products you eat, and products you drink.

Are cannabinoids nutraceuticals?

Cannabinoids are natural substances derived from Cannabis sativa, a plant with seeds that are often used for food purposes. As a result, cannabinoids loosely fit the definition of nutraceuticals, but the exact regulatory category cannabinoids belong in is currently a subject of considerable debate.

For personal or scientific purposes, it’s perfectly fine to consider cannabinoids nutraceuticals. Be careful how you describe cannabinoid products currently offered for sale, though, since mischaracterizing hemp products could get you in trouble³.

Are nutraceuticals popular?

Nutraceuticals have massively shot into popularity over the last few years. Market research analysis conducted in 20174 found that the US nutraceutical industry had already swelled from $58 billion to $71 billion over the previous three years, and it predicted the industry would be worth over $105 billion in 2022. By 2025, analysts believe the nutraceutical industry will be valued at $133.39 billion.

With the nutraceutical industry set to more than double in size in just over a decade, it’s safe to say that nutraceuticals are most definitely popular and are only getting more popular with time.

What is the nutraceutical industry worth?

In 2017, the nutraceutical industry was estimated to be worth just over $383 billion worldwide. At the time, market analytics firms suggested that it might be worth more than $561 billion by 2023.

Based on just-released research, it appears these predictions were right on the money. In April of 2022, Zion Market Research released a report estimating that the global nutraceutical industry is now worth $449.5 billion⁴ and is expected to grow to $745.5 billion by 2028.

How fast is the nutraceutical industry growing?

It’s difficult to pinpoint the exact rate of growth the nutraceutical industry is currently undergoing, but we know one thing for sure — it’s growing fast. Led by a breakneck-rate growth of interest in alternative medical care in Western countries, the global nutraceutical industry is set to double in value over the course of the decade between 2017 and 2028, mirroring recent rates of growth seen in the US.

The nutraceutical market in 2025

By 2025, the American nutraceutical market will be twice the size it was in 2015, and statistics indicate the same will be true for the global market as well. That means brands now emerging into the nutraceutical industry have twice the opportunity as brands that launched a decade ago, but they’re also facing a modernized industry with lots of competition. The best way to prepare for the nutraceutical market of 2025 is to launch an excellent brand today.

Nutraceuticals by product type

For the purposes of industry analysis, nutraceuticals are often broken down into the three subcategories we mentioned earlier: dietary supplements, functional foods, and functional beverages. As we learn about the growth of the nutraceutical industry, it can be useful to examine the growth of each individual subcategory:

What are dietary supplements?

Dietary supplements are generally classified as nutraceuticals that you take in the form of a tablet, capsule, or another concentrated product, not in the form of food or beverages. This is the type of nutraceutical for which the FDA has provided the clearest regulations.

What are functional foods?

Functional foods are edible products that are boosted with nutraceutical substances. Some functional foods, such as turmeric root, naturally contain the substances that make them nutraceuticals — in the case of turmeric, the potent antioxidant compound curcumin. With other functional foods, nutraceutical substances are added to food items to create infused edible products.

What are functional beverages?

Functional beverages are drinks that contain nutraceutical substances. The popular fermented drink kombucha, for instance, is commonly considered to be a nutraceutical due to the probiotics it contains. In other cases, conventional drinks like sparkling water are infused with cannabinoids, adaptogens, or other substances commonly considered to be nutraceuticals.

What is the fastest-growing nutraceutical product type?

In 2014’s United States, functional beverages were worth $11.2 billion, functional foods were worth 17.6 billion, and dietary supplements were worth $29.8 billion. By 2017, these subcategories had swelled to $14.8bn, $21.7bn, and $35.2bn. In 2022, functional drinks, functional foods, and dietary supplements are projected to be worth $21.7bn, $30.8bn, and $52.5bn respectively.

While dietary supplements still make up the lion’s share of the nutraceutical industry, functional drinks are actually the fastest-growing subcategory. The functional nutraceutical drink market is projected to have nearly doubled in size during the eight years between 2014 and 2022, exceeding the growth rates of other subcategories substantially.

Key takeaways

There’s a mounting trend of consumers wanting to get their health supplements from drinks. The overall benefits of staying hydrated are more well-known than ever before, and consumers are both concerned about the dangers of soft drinks and energy drinks while remaining accustomed to their sweetness and energizing benefits.

As a result, drinks designed to make you feel energized using nutraceutical substances are becoming increasingly popular. However, anti-anxiety and anti-insomnia nutraceutical drinks are just as in-demand.

Even though functional drinks represent the fastest-growing nutraceutical subcategory, this category is still the smallest overall. There may be more competition and less growth potential in dietary supplements and functional foods, but that’s still where most of the capital is invested.

The growing importance of nutraceuticals

Nutraceuticals aren’t going away. Even the verbiage surrounding this class of substances is archaic, so it’s understandable that regulatory agencies are taking a while to grapple with this facet of the natural health revolution. It’s a fact that hundreds of natural, edible substances have massive health benefits, though, leading to an enhanced focus on nutraceuticals among health-conscious consumers.

So far, projected growth rates for the nutraceutical industry have been right on track. They may, in fact, have been a bit pessimistic. Right now, the idea of a $130 billion-per-year US nutraceutical industry can sound far-fetched, but there’s a lot going for nutraceuticals.

Especially in these pandemic-impacted times, people are looking for new ways to improve their immunity or boost their overall health. The benefits of nutraceuticals speak for themselves, and they’ll start speaking even louder over the coming years.

Nutraceuticals FAQs

1. What are the basics of nutraceuticals?

In a nutshell, nutraceuticals are “natural pharmaceuticals” — they’re substances with near-pharmaceutical potency that are nonetheless found in nature. The name “nutraceutical,” however, etymologically comes from the words “nutritional” and “pharmaceutical,” which is to say that nutraceuticals are medicinal foods.

So, put all together, nutraceuticals are natural pharmaceuticals that you eat. Not all products described or labeled as “nutraceuticals,” however, have nutritional value or are even orally ingested. Therefore, despite the implications inherent to the name, nutraceutical can only truly be said to mean “natural healing substance.”

2. What are the most commonly used nutraceuticals?

Some of the nutraceuticals that average people use most commonly are vitamins, minerals, and plant oil extracts like terpenes and cannabinoids. While some definitions of the term do not include vitamins and minerals, nutraceuticals are widely understood as bridging a wide spectrum of different medicinally beneficial, orally ingested substances.

Vitamins and minerals have been used as supplements for decades. It’s only more recently, though, that plant extracts like essential oils, terpenes, and cannabinoids have also entered the nutraceutical market in full force. Shoppers now understand that many plant extracts have benefits on par with or even exceeding those of vitamins and minerals.

3. Did the FDA approve nutraceuticals?

The FDA has approved certain substances sometimes known as nutraceuticals for certain conditions. This government agency, however, has not approved nutraceuticals as a general category of substances.

The FDA does not even have an official definition of nutraceuticals. On the agency’s official website, the only mention of the word “nutraceutical” is in association with public postings of false claim filings against offending supplement producers.

4. Are nutraceuticals regulated in the US?

As a general category of substances, nutraceuticals are not regulated by any federal government agency in the United States. The same is the case in Europe, wherein the European Union likewise does not define nutraceuticals as a distinct product category for regulatory purposes.

Specific substances labeled as nutraceuticals, though, are very likely to be regulated in the United States. When determining the regulatory procedures for a certain nutraceutical substance, research its status individually.

Summary: Nutraceuticals and cannabinoids are converging

Directly calling cannabinoids “nutraceuticals” can be a regulatory risk, but it’s worth noting how seamlessly the hemp industry is being enfolded within the overall nutraceutical market. CBD is now a popular substance in all manner of dietary supplements, and we’re even starting to see the emergence of food and drink products infused with rarer cannabinoids like CBN and CBC.

Whether it’s nutraceuticals or cannabinoids, the infused food and drink market shouldn’t be overlooked. Today’s consumers don’t always want to take health supplements in pills: They want to eat or drink them the same way they would anything else. If there’s one prediction you should take away from this analysis, it’s that nutraceutical and cannabinoid-infused food and drinks will become even more popular than anyone currently expects over the coming years.

Sources

1. 1. Santini, A., Cammarata, S. M., Capone, G., Ianaro, A., Tenore, G. C., Pani, L., & Novellino, E. (2018). Nutraceuticals: opening the debate for a regulatory framework. British Journal of Clinical Pharmacology, 84(4), 659–672. https://doi.org/10.1111/bcp.13496
2. 2. Carrasco-Gallardo, C., Guzmán, L., & Maccioni, R. B. (2012). Shilajit: A Natural Phytocomplex with Potential Procognitive Activity. International Journal of Alzheimer’s Disease, 2012, 1–4. https://doi.org/10.1155/2012/674142
3. 3. Office of the Commissioner. (2022, May 6). Warning Letters and Test Results for Cannabidiol-Related Products. U.S. Food and Drug Administration. https://www.fda.gov/news-events/public-health-focus/warning-letters-and-test-results-cannabidiol-related-products
4. 4, Nutraceuticals Market Size, Trends, Growth | Industry Analysis (2022–27). (2022). Mordor Intelligence. https://www.mordorintelligence.com/industry-reports/global-nutraceuticals-market-industry
5. 5. Research, Z. M. (2022, April 20). Growth Scope of Nutraceuticals Market Size Worth USD 745.5 Billion By 2028 At 8.8% CAGR – Industry Trends & Forecast Report by Zion Market Research. PR Newswire. https://www.prnewswire.com/news-releases/growth-scope-of-nutraceuticals-market-size-worth-usd-745-5-billion-by-2028-at-8-8-cagr—industry-trends–forecast-report-by-zion-market-research-301529003.html

The American CBD industry is in full swing. With more than 14% of Americans using CBD products¹ and the hemp market swelling to $24.5 billion per year², hemp has become a force to be reckoned with.

A disproportionate number of CBD sales occur online, however, with far fewer Americans buying this cannabinoid from brick-and-mortar retailers. What’s the basis behind this trend, and what does it mean for CBD brands that want to succeed in today’s rapidly shifting environment?

In this guide, we’ll use the latest data to explain why US consumers choose to buy CBD online and lay out a path to success for operators in the American hemp space. Discover the factors driving online hemp sales and what they mean for the future of the CBD market.

Current status of the US CBD market

American CBD remains largely in the same strange place that the 2018 Farm Bill left it. This landmark piece of hemp legislation firmly separated CBD from THC and put the cannabinoid in the FDA’s court. Citing long-standing industry precedent and a continuing lack of clinical safety information, though, the FDA has been reluctant to fully legitimize CBD sales in the United States.

In 2017, the FDA approved Epidiolex as a prescription drug. Once the FDA has approved a substance as a prescription drug, it doesn’t generally approve the same substance for over-the-counter use. While Epidiolex generates a genuine conflict for the FDA, it’s also possible the federal agency is dragging its heels in anticipation of the improved clarity that would accompany successful federal cannabis reform legislation.

What do US consumers use CBD for?

American consumers don’t seem to be particularly perturbed by the FDA’s lack of comprehensive CBD guidance. They continue to use this non-intoxicating cannabinoid in record numbers, and they’re increasingly turning to CBD for help with issues aside from pain and inflammation.

A 2019 Quartz survey⁴, for instance, found that 55% of Americans who had used CBD had tried it for general relaxation, and a further 50% had used it for stress or anxiety. Forty-five percent of US CBD consumers had used the cannabinoid for sleep with only 39% relying on it for pain.

This information clearly indicates that CBD is reaching a much wider audience than before. Average Americans — not just those suffering from pain — are discovering the many ways CBD can benefit their lives, driving sales of this cannabinoid ever higher.

Where do American consumers buy CBD?

A 2021 Nielsen survey⁵ shed light on American CBD buying behavior by showing where US consumers are now purchasing their hemp products. Unsurprisingly, the vast majority of American hemp users buy CBD online, an existing trend that the pandemic significantly exacerbated.

Why do so many Americans buy CBD on the internet, and where else do they buy this cannabinoid? Let’s take a look:

1. Online

How many Americans buy CBD online?

According to the Nielsen survey, 66% of Americans now buy CBD online. The internet has always been the primary marketplace for hemp products, but 2/3 of hemp sales being conducted online is an unprecedented portion.

Why do Americans buy CBD online?

As with all other types of products, buying CBD online is easy and convenient. Some states still have laws restricting sales of certain kinds of CBD products, often making the type of CBD consumers want only available online.

During the pandemic, many of the smaller stores that traditionally carried CBD shut down or vastly curtailed their business activities. As a result, many consumers who had previously preferred to buy CBD in person were forced to start purchasing products online. Now, many of them haven’t elected to go back.

The Future of US Online CBD sales

Expect online CBD sales to take up an ever-greater share of the market over the coming years. Buying products online only gets easier as time goes by, and as more consumers enter the hemp market, their overall predisposition towards Ecommerce will skew CBD sales even further toward online channels. Barring some massive disruption of domestic shipping services, CBD sales are highly likely to continue to gravitate toward online ecosystems.

2. Specialty stores

How many Americans buy CBD at specialty stores?

Since the early days of CBD, Americans have relied on specialty stores like natural food stores and vape shops to supply their favorite hemp products. As of 2021, 29-31% of them still did, with shares of brick-and-mortar CBD sales recovering somewhat from 2020’s lows.

Why do Americans buy CBD at specialty stores?

With around a third of American CBD consumers still buying CBD from their favorite local mom-and-pop shops, it’s clear there’s something about the sales model that’s working. Familiarity with store staff and the benefits of one-on-one product selection assistance outweigh the convenience of buying CBD products online for some consumers, and others simply appreciate the convenience of being able to buy CBD during their normal trips to the store.

The future of US specialty store CBD sales

No matter how successful Ecommerce may become, the local economy isn’t simply going to disappear. Natural food stores, vape stores, smoke shops, boutiques, and other CBD-carrying retailers will continue to exist, and their owners will continue to capitalize on CBD’s enduring popularity. The share of US consumers who buy their CBD in-person, however, is almost sure to drop at least somewhat over the coming years.

3. Chain stores

How many Americans buy CBD at chain stores?

Over the last five years or so, major grocery store chains (most notably Kroger⁶) have given the green light to regional buyers who want to onboard CBD products. Despite corporate America’s attempts to mainstream CBD, however, only 3-5% of CBD consumers choose to buy their hemp products from major consumer packaged goods (CPG) stores.

Why do Americans buy CBD at chain stores?

No matter how much you might love CBD, this cannabinoid isn’t what you’re expecting to see on the shelves of your local conventional grocery store. The slow growth of the share of CBD sales occurring in CPG retail environments is due somewhat to the overall newness of the phenomenon but also to a lack of education among both store employees and customers regarding the benefits of CBD.

American CBD consumers often go to specialty stores in search of particular hemp products, and mainstream CPG retailers — which generally only stock a few CBD SKUs — can’t possibly carry every brand consumers seek. Often turned away by the lack of product variety carried in major chains, this hemp sales channel has yet to truly take flight.

Key takeaways

Let’s summarize all this information in a few bullet points:

• 66% of Americans buy CBD online, 29-31% buy it from specialty stores, and 3-5% buy it from major CPG retailers
• Online CBD sales strengthened during the pandemic and show no signs of slowing down
• Many American CBD users also still buy from their local mom-and-pop shops
• Far fewer have migrated to buying CBD from CPG retailers
• Going forward, online sales are likely to increase at a rapid pace
• CPG CBD sales will also probably grow, but more slowly
• Specialty stores may slowly lose their share of the CBD market due to competition from CPG retailers

How to leverage American CBD buying habits

The obvious answer here is to sell CBD online. Two-thirds of American hemp consumers buy their CBD on the internet, giving you access to the largest share of the US market.

The bar-to-entry for online CBD sales can be high, however. With so many brands now jostling for space, CBD operators have to dance between product differentiation and pricing adjustments to stay distinct and attractive to consumers.

If you want to reach the largest segment of American CBD consumers and thereby set yourself with the most opportunities for profit and success, focusing largely on internet sales is the best approach. Leave yourself open to selling CBD in specialty stores, however, and always be on the lookout for opportunities to enter the nation’s slow-growing consumer packaged goods CBD market.

US retail CBD consumption FAQs

Learn more about CBD consumption in retail stores below:

1. Which major retailers sell CBD?

Some of the major retail chains that now sell CBD products include Walgreens, CVS, Kroger, and Wegmans. Not all retail chains have gotten on the bandwagon, however, with big box stores like Target, Walmart, and Costco notably staying clear.

Even if your ideal store doesn’t carry CBD, chances are that a nearby retailer does. In any case, the type of quality you can get with online CBD usually far outstrips anything you’ll find in a retail store.

2. Is there CBD at Walmart?

No, Walmart does not sell CBD products. There are a few listings on walmart.com that, at first glance, appear to be for products containing CBD.

It only takes a cursory look, however, to recognize that these products do not actually contain any CBD at all. If they did, they would immediately be flagged for removal by Walmart.

3. Are CBD products sold at CVS?

Yes, CVS is one of a number of drug store chains that have adopted the CBD revolution wholeheartedly. You can buy CBD products made by major, recognized brands at almost every CVS location.

Alongside CBD products made by brands that originally started on the internet are anonymous, generic products made by the drug store brand’s existing distributors. If shopping for CBD products at CVS, always go with brands that are also sold online and have a considerable national following.

4. Does Walgreens sell CBD?

Yes, CBD products are widely available at most Walgreens stores nationwide. Almost all the CBD products sold at Walgreens, however, are produced by the drug store company’s in-house manufacturers.

As another option, visit a natural food store for better CBD product quality. Whole Foods is an example of a national food co-op chain that sells CBD, and many local co-ops do as well.

Summary: US CBD sales channels are evolving

The pandemic changed many things — not the least consumer buying behavior. According to the United States Census Bureau⁷, online sales shot up 43% in 2020, exploding from $571.2 billion in 2019 to $815.4 billion in a single year.

And, like many pandemic-inspired changes, this unprecedented shift toward online sales doesn’t seem to be going anywhere anytime soon. Consumers are already buying more products online, so it simply makes sense to buy CBD online now too.

There will never come a point, however, when 100% of CBD sales occur online. As you pivot toward today’s internet-driven CBD economy, never forget to explore potentially lucrative opportunities for diversification offered by brick-and-mortar retail environments.

Sources

1. 1. Brenan, B. M. (2021, November 20). 14% of Americans Say They Use CBD Products. Gallup.Com. https://news.gallup.com/poll/263147/americans-say-cbd-products.aspx
2. 2. Gelsi, S. (2022, May 4). Legal cannabis sales exceed Starbucks N. America sales in 2021: Report. MarketWatch. https://www.marketwatch.com/story/legal-cannabis-sales-exceed-starbucks-n-america-sales-in-2021-report-2022-05-04
3. 3. Drotleff, L. (2022, June 2). Federal cannabis legalization may affect FDA’s approach to CBD regulation, experts say. Hemp Industry Daily. https://hempindustrydaily.com/federal-cannabis-legalization-may-affect-fdas-approach-to-cbd-regulation-experts-say/
4. 4. Kopf, D., & Avins, J. (2020, February 23). Survey shows Americans use CBD to treat anxiety and stress. Quartz. https://qz.com/1590765/survey-shows-americans-use-cbd-to-treat-anxiety-and-stress/
5. 5. Staff, H. I. D. (2021, March 15). Chart: Top CBD sales channels in 2020. Hemp Industry Daily. https://hempindustrydaily.com/chart-top-cbd-sales-channels/
6. 6. LaVito, A., & Hirsch, L. (2019, June 12). Kroger to sell CBD products in nearly 1,000 stores. CNBC. https://www.cnbc.com/2019/06/11/kroger-to-sell-cbd-products-in-nearly-1000-stores.html
7. 7. U.S. Census Bureau. (2022, April 26). Annual Retail Trade Survey Shows Impact of Online Shopping on Retail Sales During COVID-19 Pandemic. Census.Gov. https://www.census.gov/library/stories/2022/04/ecommerce-sales-surged-during-pandemic.html